Monday, 27 February 2017

Cerebral palsy: Symptoms, causes, and treatments

Cerebral palsy is a term used to describe a set of neurological conditions that affect movement. It is the most common form of childhood disability.
It affects around 764,000 individuals in the United States.
The condition makes it hard to move certain parts of the body. There are many degrees of severity.
Because of damage to certain parts of the brain, voluntary or involuntary movements or both can be affected.
Cerebral palsy is not contagious, it does not necessarily affect intelligence or cognitive ability, and it is not progressive, so it does not get worse with age. Some people find that symptoms improve over time.
People with cerebral palsy tend to have a normal lifespan, and in many cases, a good quality of life can be expected.
Contents of this article:
  1. Symptoms and types
  2. Causes
  3. Diagnosis
  4. Treatment and prevention
  5. Cerebral palsy in adulthood

Symptoms and types

Features can include:An infant with cerebral palsy may have muscular and movement problems, including poor muscle tone. Muscle tone refers to a person's automatic ability to tighten and relax muscle when required.
  • Overdeveloped or underdeveloped muscles, leading to stiff or floppy movements
  • Poor coordination and balance, known as ataxia
  • Involuntary, slow writhing movements, or athetosis
  • Stiff muscles that contract abnormally, known as spastic paralysis
  • Crawling in an unusual way
  • Lying down in awkward positions
  • Favoring one side of the body over the other
  • A limited range of movement
Other signs and symptoms include:
  • Late achievement of developmental milestones such as crawling, walking, or speaking
  • Hearing and eyesight problems
  • Problems controlling bladder and bowel movements
  • Seizures
  • Drooling, and problems with feeding, sucking, and swallowing
  • Being easily startled
Symptoms normally start to show during the first 3 years of life.

Types

There are four types of cerebral palsy: Spastic, athetoid-dyskinetic, ataxic, and hypotonic.

Spastic cerebral palsy

There are three different types of spastic cerebral palsy.
Spastic diplegia: The lower limbs are affected, and the upper body has no spasticity or only a little. The leg and hip muscles are tight. Legs cross at the knees, making walking more difficult. The crossing of the legs when upright is often referred to as scissoring.Spastic hemiplegia: A child with spastic hemiplegia will typically have spasticity, or muscle stiffness, on one side of the body. This is usually just a hand and an arm, but it may also involve a leg. The side that is affected may not develop properly. There may be speech problems. Intelligence is not usually affected. Seizures may occur.
Spastic quadriplegia: The legs, arms, and body are affected. This is the most severe form of spastic cerebral palsy. It may involve cognitive deficits. Walking and talking will be difficult. Seizures may occur.

Athetoid or dyskinetic cerebral palsy

Also known as athetoid dyskinetic cerebral palsy, this is the second most common type. Intelligence is usually normal, but muscle problems affect the whole body. Weak or tight muscle tone causes random and uncontrolled body movements.
The child will have problems walking, sitting, maintaining posture, and speaking clearly because the tongue and vocal cords are hard to control. Some children drool if they have problems controlling facial muscles.

Ataxic cerebral palsy

Balance and coordination are most affected. Tasks that need fine motor skills will be difficult, such as tying shoelaces, buttoning up shirts, and cutting with scissors.
Balance difficulties may cause the child to walk with their feet far apart. Most children with ataxic cerebral palsy have normal intelligence and good communication skills, but some may have erratic speech.

Hypotonic cerebral palsy

Hypotonic cerebral palsy results from an injury to the cerebellum.
Muscle problems appear earlier. The infant's head and body will be floppy, "like a rag doll." There is only moderate resistance when an adult tries to move the infant's limbs. The infant may rest with their elbows and knees loosely extended, instead of flexed. There may be breathing difficulties.

Causes

Muscle control takes place in a part of the brain called the cerebrum. The cerebrum is the upper part of the brain. Damage to the cerebrum before, during, or within 5 years of birth can cause cerebral palsy.
Some newborns are deprived of oxygen during labor and delivery.The cerebrum is also responsible for memory, ability to learn, and communication skills. This is why some people with cerebral palsy have problems with communication and learning. Cerebrum damage can sometimes affect vision and hearing.
In the past, it was thought that this lack of oxygen during birth led to the brain damage.
However, during the 1980s, research showed that fewer than 1 in 10 cases of cerebral palsy stem from oxygen deprivation during birth.
Most often, the damage occurs before birth, probably during the first 6 months of pregnancy.
There are at least three possible reasons for this. 

Periventricular leukomalacia (PVL)

PVL is a kind of damage that affects the brain's white matter because of a lack of oxygen in the womb.
It may occur if the mother has an infection during pregnancy, such as rubella or German measles, low blood pressure, preterm delivery, or if she uses an illegal drug.

Abnormal development of the brain

Disruption of brain development can affect the way the brain communicates with the body's muscles and other functions.
During the first 6 months of pregnancy, the brain of the embryo or fetus is particularly vulnerable.
Damage can stem from mutations in the genes responsible for brain development, certain infections such as toxoplasmosis, a parasite infection, herpes and herpes-like viruses, and head trauma.

Intracranial hemorrhage

Sometimes, bleeding inside the brain happens when a fetus experiences a stroke.
Bleeding in the brain can stop the supply of blood to vital brain tissue, and this tissue can become damaged or die. The escaped blood can clot and damage surrounding tissue.
Several factors can cause a stroke in a fetus during pregnancy:
  • A blood clot in the placenta that blocks the flow of blood
  • A clotting disorder in the fetus
  • Interruptions in arterial blood flow to the fetal brain
  • Untreated pre-eclampsia in the mother
  • Inflammation of the placenta
  • Pelvic inflammatory infection in the mother
During delivery, the risk is increased by the following factors:
  • Emergency cesarean
  • The second stage of labor is prolonged
  • Vacuum extraction is used during delivery
  • Fetal or neonatal heart anomalies
  • Umbilical cord abnormalities
Anything that increases the risk of preterm birth or low birth weight also raises the risk of cerebral palsy.
Factors that may contribute to a higher risk of cerebral palsy include:
  • Multiple births, for example, twins
  • Damaged placenta
  • Sexually transmitted infections (STIs)
  • Consumption of alcohol, illegal drugs, or toxic substances during pregnancy
  • Malnourishment during pregnancy
  • Random malformation of the fetal brain
  • Small pelvis in the mother
  • Breech delivery

Brain damage after birth

A small proportion of cases happen because of damage after birth. This can happen because of an infection such as meningitis, a head injury, a drowning accident, or poisoning.
When damage occurs, it will do so soon after the birth. With age, the human brain becomes more resilient and able withstand more damage.

Diagnosis

Any parent who is concerned about their child's development should see their doctor.
The doctor will ask the parents about the infant's history and development and the mother's medical history during her pregnancy.
The doctor will examine the child and observe their posture, movements, muscle tone, motor skills, and they will check the child's reflexes.
If age-appropriate, the doctor may refer the child to an educational psychologist to assess intellectual development.

Ruling out other conditions

Other conditions with similar symptoms may need to be ruled out, such as a tumor or muscular dystrophy.
Tests that can help with diagnosis include:
  • Blood tests
  • Head ultrasound
  • MRI or CT scan
At the age of 2 to 3 years, a more comprehensive diagnosis of cerebral palsy is usually possible, but the severity is not usually fully assessed until the age of 4 to 5 years.
A diagnosis of cerebral palsy requires regular assessments, to make comparisons and determine what the developmental needs and issues are.
It takes time to make a comprehensive and confident diagnosis, as a careful assessment must be carried out several times.

Treatment and prevention

There is no cure for cerebral palsy, but treatment can help manage symptoms and increase independence.
When a child receives a diagnosis of cerebral palsy, a team of health professionals will help to look after their needs. The team may include a doctor, a pediatrician, a speech therapist, and an educational psychologist, among others.
An individual care plan will address the needs of the child and the family. As the child gets older, the plan will be reviewed and revised.
Treatment depends entirely on individual needs. The aim is to help the child achieve as much independence as possible.

Prevention

Most of the time, it is not possible to prevent cerebral palsy, but some actions can reduce the risk.
A woman who is planning to become pregnant should ensure that all her vaccinations are up-to-date.
During pregnancy, it is important to:
  • Attend all antenatal appointments
  • Avoid alcohol, tobacco, and illegal drugs
  • Carry out regular exercise, according to the physician's advice
  • Eat healthily
For second or subsequent pregnancies, it may be useful to identify potential Rh incompatibility, as this can increase the risk of cerebral palsy.

Cerebral palsy in adulthood

Because cerebral palsy is non-progressive, it will not worsen as the individual ages; however, it is likely to present certain difficulties. These difficulties generally fall into two categories - motor and intellectual.
The most common challenges to individuals with cerebral palsy as they age are:
  • Walking - because cerebral palsy affects movement and flexibility, musculoskeletal abnormalities can worsen as the person ages. This may necessitate the use of mobility aids, such as a stick or wheelchair.
  • Swallowing problems - known as dysphagia, problems with swallowing are common. They are generally caused by damage to the nerves in the neck or head. Symptoms can include coughing after eating or drinking, food getting stuck in the mouth, pneumonia, weight loss, and poor nutrition. Working with a speech or physical therapist can help.
  • Premature aging - although the total lifespan of individuals with cerebral palsy is similar to the general population, some signs of aging can arrive early. Because the condition puts additional strain on the body, there can be increased pain when, for instance, climbing the stairs. There is also an increased risk of dental problems, falls, and stiff muscles.
  • Post-impairment syndrome - this is caused due to the increased energy that it takes to move around. Symptoms include weakness, increased pain, repetitive strain injuries, and fatigue. Working with a therapist can help strengthen the muscles most affected by the condition.
  • Mental health conditions - due to social stress, bullying, or teasing, individuals with cerebral palsy are more likely to become shy in social situations and have depression or anxiety disorders.

Although adulthood with cerebral palsy can be challenging, there is no reason that an individual can not enjoy a fulfilling and positive life.


 ©lionelmyth

Rights of Persons with Disabilities Bill

Press Information Bureau 
Government of India
Ministry of Social Justice & Empowerment
-----------------------------------------------------------------------------------------------
The Lok Sabha passed "The Rights of Persons with Disabilities Bill - 2016". The Bill will replace the existing PwD Act, 1995, which was enacted 21 years back. The Rajya Sabha has already passed the Bill on 14.12.2016.
  The salient features of the Bill are:
                    i.          Disability has been defined based on an evolving and dynamic concept.
                  ii.          The types of disabilities have been increased from existing 7 to 21 and the Central Government will have the power to add more types of disabilities. The 21 disabilities are given below:-
1.                  Blindness
2.                  Low-vision
3.                  Leprosy Cured persons
4.                  Hearing Impairment (deaf and hard of hearing)
5.                  Locomotor Disability
6.                  Dwarfism
7.                  Intellectual Disability
8.                  Mental Illness
9.                  Autism Spectrum Disorder
10.              Cerebral Palsy
11.              Muscular Dystrophy
12.              Chronic Neurological conditions
13.              Specific Learning Disabilities
14.              Multiple Sclerosis
15.              Speech and Language disability
16.              Thalassemia
17.              Hemophilia
18.              Sickle Cell disease
19.              Multiple Disabilities including deafblindness
20.              Acid Attack victim
21.              Parkinson's disease
           iii.              Speech and Language Disability and Specific Learning Disability have been added for the first time. Acid Attack Victims have been included. Dwarfism, muscular dystrophy have has been indicated as separate class of specified disability. The New categories of disabilities also included three blood disorders, Thalassemia, Hemophilia and Sickle Cell disease.
                iv.          In addition, the Government has been authorized to notify any other category of specified disability.
                  v.          Responsibility has been cast upon the appropriate governments to take effective measures to ensure that the persons with disabilities enjoy their rights equally with others.
           vi.              Additional benefits such as reservation in higher education, government jobs, reservation in allocation of land, poverty alleviation schemes etc. have been provided for persons with benchmark disabilities and those with high support needs.
         vii.              Every child with benchmark disability between the age group of 6 and 18 years shall have the right to free education.
       viii.              Government funded educational institutions as well as the government recognized institutions will have to provide inclusive education to the children with disabilities.
           ix.              For strengthening the Prime Minister's Accessible India Campaign, stress has been given to ensure accessibility in public buildings (both Government and private) in a prescribed time-frame.
             x.              Reservation in vacancies in government establishments has been increased from 3% to 4% for certain persons or class of persons with benchmark disability.
           xi.              The Bill provides for grant of guardianship by District Court under which there will be joint decision – making between the guardian and the persons with disabilities.
         xii.              Broad based Central & State Advisory Boards on Disability are to be set up to serve as apex policy making bodies at the Central and State level.
       xiii.              Office of Chief Commissioner of Persons with Disabilities has been strengthened who will now be assisted by 2 Commissioners and an Advisory Committee comprising of not more than 11 members drawn from experts in various disabilities.
       xiv.              Similarly, the office of State Commissioners of Disabilities has been strengthened who will be assisted by an Advisory Committee comprising of not more than 5 members drawn from experts in various disabilities.
         xv.              The Chief Commissioner for Persons with Disabilities and the State Commissioners will act as regulatory bodies and Grievance Redressal agencies and also monitor implementation of the Act.
       xvi.              District level committees will be constituted by the State Governments to address local concerns of PwDs. Details of their constitution and the functions of such committees would be prescribed by the State Governments in the rules.
     xvii.              Creation of National and State Fund will be created to provide financial support to the persons with disabilities. The existing National Fund for Persons with Disabilities and the Trust Fund for Empowerment of Persons with Disabilities will be subsumed with the National Fund.
   xviii.              The Bill provides for penalties for offences committed against persons with disabilities and also violation of the provisions of the new law.
       xix.              Special Courts will be designated in each district to handle cases concerning violation of rights of PwDs.

 ©lionelmyth



Sunday, 26 February 2017

Epilepsy: Causes, Symptoms and Treatments



People with epilepsy tend to have recurrent seizures (fits). The seizures occur because of a sudden surge of electrical activity in the brain - there is an overload of electrical activity in the brain. This causes a temporary disturbance in the messaging systems between brain cells. During a seizure the patient's brain becomes "halted" or "mixed up".
Every function in our bodies is triggered by messaging systems in our brain. What a patient with epilepsy experiences during a seizure will depend on what part of his/her brain that epileptic activity starts, and how widely and quickly it spreads from that area. Consequently, there are several types of seizures and each patient will have epilepsy in his/her own unique way.
The word "epilepsy" comes from the Greek word epi meaning "upon, at, close upon", and the Greek word Leptos meaning "seizure". From those roots we have the Old French word epilepsie, and Latin word epilepsia and the Greek words epilepsia and epilepsies.

How common is epilepsy?

Approximately 50 out of every 100,000 people develop epilepsy each year in industrialized nations.
Epilepsy in UK - according to Epilepsy Action 460,000 people in the United Kingdom have epilepsy.

Epilepsy in USA - according to The Epilepsy Foundation over 3 million Americans are affected by epilepsy and seizures. About 200,000 new cases of seizures and epilepsy occur in the USA each year. 10% of all Americans will experience a seizure some time during their lifetime.
Epilepsy worldwide - according to The National Society for Epilepsy (UK)about 50 million people have epilepsy globally.

Symptoms of epilepsy

The main symptoms of epilepsy are repeated seizures. There are some symptoms which may indicate a person has epilepsy. If one or more of these symptoms are present a medical exam is advised, especially if they recur:
  • A convulsion with no temperature (no fever).
  • Short spells of blackout, or confused memory.
  • Intermittent fainting spells, during which bowel or bladder control is lost. This is frequently followed by extreme tiredness.
  • For a short period the person is unresponsive to instructions or questions.
  • The person becomes stiff, suddenly, for no obvious reason
  • The person suddenly falls for no clear reason
  • Sudden bouts of blinking without apparent stimuli
  • Sudden bouts of chewing, without any apparent reason
  • For a short time the person seems dazed, and unable to communicate
  • Repetitive movements that seem inappropriate
  • The person becomes fearful for no apparent reason, he/she may even panic or become angry
  • Peculiar changes in senses, such as smell, touch and sound
  • The arms, legs, or body jerk, in babies these will appear as cluster of rapid jerking movements.
The following conditions need to be eliminated as they may present similar symptoms, and are sometimes misdiagnosed as epilepsy:
  • A high fever with epilepsy-like symptoms
  • Fainting
  • Narcolepsy (recurring episodes of sleep during the day and often disrupted nocturnal sleep)
  • Cataplexy (a transient attack of extreme generalized weakness, often precipitated by an emotional response, such as surprise, fear, or anger; one component of the narcolepsy quadrad)
  • Sleep disorders
  • Nightmares
  • Panic attacks
  • Fugue states (a rare psychiatric disorder characterized by reversible amnesia for personal identity)
  • Psychogenic seizures (a clinical episode that looks like an epileptic seizure, but is not due to epilepsy. The EEG is normal during an attack, and the behavior is often related to psychiatric disturbance, such as a conversion disorder)
  • Breath-holding episodes (when a child responds to anger there may be vigorous crying and subsequent apnea and cyanosis - the child then stops breathing and skin color changes with loss of consciousness).

Treatments for epilepsy

When a diagnosis of seizures or epilepsy is made, the doctor will then discuss with the patient or the patient's family what the best treatment options are. If an underlying correctable brain condition was causing the seizures, sometimes surgery may stop them. If epilepsy is diagnosed (ongoing tendency to have seizures), the doctor will prescribe seizure-preventing drugs or anti-epileptic drugs.
If drugs do not work, the next option could be surgery, a special diet or VNS (vagus nerve stimulation). Trigeminal nerve stimulation may also be effective, according to this study.
The doctor's aim is to prevent further seizures from occurring, while at the same time avoiding side-effects so that the patient may lead a normal, active, and productive life.

Anti-epileptic drugs (AEDs)

The majority of AEDSs are taken orally. The type of seizure the patient is having will decide which drug the doctor may prescribe. We do not all react in the same way to drugs; while some of us may experience side effects from one type of medication, others will not. Some drugs effectively stop further seizures from occurring with one patient who has a certain type of epilepsy, while another patient with the same type will experience no benefit from that same drug. Even when the right drug is found, it could take some time to find the ideal dose.
Famous people who have/had epilepsy:
Agatha Christie (writer)
Alexander the Great (monarch)
Alfred Nobel (scientist)
Alfred the Great (monarch)
Aristotle (philosopher)
Bud Abbot (actor, comedian)
Charles Dickens (writer)
Charles V (Spanish monarch)
Danny Glover (actor)
Edgar Allen-Poe (writer)
George F. Handel (musician)
Hannibal (military commander)
Julius Caesar (emperor)
Leonardo da Vinci (artist)
Lewis Carroll (writer)
Lord Byron (writer)
Louis XIII (monarch)
Martin Luther (theologian)
Michelangelo (artist, sculptor)
Napoleon Bonaparte (Emperor)
Neil Young (musician)
Nicolo Paganini (musician)
Peter Tchaikovsky (musician)
Pythagoras (mathematician)
Richard Burton (actor)
Sir Isaac Newton (scientist)
T. Roosevelt (statesman)
Vincent Van Gogh (artist)
AEDs are aimed at modifying the structures and processes involved during the development of a seizure; including neurons, receptors, glia, ion channels and inhibitory or excitatory synapses. Inhibition is triggered to stop or prevent seizure activity.
Children take the same AEDs as adults. They may be present as tablets, capsules, syrups or sprinklers. As in the case of treating adults, AEDs are designed to prevent seizures. Some are effective with a limited number of types of seizure, while others may treat a broader range. Doctors will try to control seizures with just one drug, but some children may need to take more than one. The success of childhood AEDs also depends to a great extent on compliance - following instructions carefully (not forgetting to take them).
Here is a list of the most commonly prescribed anti-epileptic drugs (AEDs).
  • acetazolamide (brand name Diamox)
  • acetazolomide modified release (brand name Diamox SR)
  • carbamazepine (brand name Tegretol)
  • carbamazepine modified release (brand name Tegretol Retard)
  • clobazam (brand name Frisium )
  • clonazepam (brand name Rivotril)
  • ethosuximide (brand names Emeside - Zarontin)
  • gabapentin (brand name Neurontin)
  • lacosamide (brand name Vimpat)
  • lamotrigine (brand name Lamictal )
  • levetiracetam (brand name Keppra)
  • oxcarbazepine (brand name Trileptal phenobarbital)
  • perampanel (brand name Fycompa) tablets as an adjunctive treatment for partial onset seizures in epilepsy were approved by the FDA on Monday 22nd October, 2012. Fycompa is already approved in the European Union (27 sovereign states), Norway and Iceland, and is made and marketed by Eisai.
  • phenytoin (brand name Epanutin)
  • pregabalin (brand name Lyrica)
  • primidone (brand name Mysoline)
  • rufinamide (brand name Inovelon)
  • sodium valproate (brand names Epilim - Episenta)
  • sodium valproate modified release (brand name Epilim Chrono)
  • tiagabine (brand name Gabitril )
  • topiramate (brand name Topamax)
  • valproic acid (brand name Convulex)
  • vigabatrin (brand name Sabril)
  • zonisamide (brand name Zonegran)

The prognosis for epilepsy sufferers

Experts say that about 60% of people who are untreated have no further seizures during the 24 months following their first seizure. The outlook (prognosis) for most people with epilepsy is good. Approximately 70% go into remission for 5 years on or off treatment (no seizures for five years). About 20% to 30% develop chronic epilepsy (long term epilepsy) - these people are generally treated with AEDs.

 ©lionelmyth